Yaoxi He

This study identifies Neanderthal-derived adaptive variation in Tibetans, showing functional convergence in immune and metabolic pathways, beyond the well-known EPAS1 locus.

The paper presents 320 nearly-complete East Asian genome assemblies, revealing new genetic diversity and structural variations not present in existing global pangenomes.

Over 8,000 gapless human centromeres reveal population-stratified satellite-array, inversion and haplotype variation, multiple candidate kinetochore sites in 16.8% of centromeres, and single-base substitution rates comparable to flanking pericentromeres.

This paper presents a near-complete lamprey genome assembly, revealing gene family expansions and regulatory elements linked to vertebrate innovations.

The paper responds to concerns about the reliability of ancient DNA sequences from a Late Pleistocene individual, arguing that observed patterns are better explained by aDNA damage and technical artefacts than modern contamination.

This study presents genome assemblies and analyses of macaques to explore genetic variation, population history, and evolutionary differences between species and humans.

The paper identifies great-ape-specific structural variants and their potential role in evolutionary phenotypic innovations.

SpecVar improves heritability enrichment by integrating regulatory networks with GWAS data to identify relevant tissues and shared heritability.

The paper assembles a high-quality Tibetan genome and identifies structural variants linked to high altitude adaptation and archaic hominid ancestry.

The paper presents a high-quality long-read genome assembly of the Chinese rhesus macaque and identifies ape-specific structural variants.

The paper uses whole genome trio sequencing to assess off-target effects of Cas9 editing in monkeys and finds no unexpected mutations.