Author

Lei Nie

Zhejiang University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Same name, identified by ORCID

Biology Disciplines

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Genomics· 2 Cell Biology· 1 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:database / resource· 2 Approach:statistical model· 2 Research Focus:variant calling· 2 Assay:whole-genome sequencing· 2 Research Focus:benchmarking· 1 Assay:CUT&Tag· 1

Frequent Co-Authors

Dan YuiD· 3 shared Guojie ZhangiD· 3 shared Quanyu CheniD· 3 shared Yanqing SuniD· 3 shared An LiuiD· 2 shared Aoyue BiiD· 2 shared Bing SuiD· 2 shared Dongya WuiD· 2 shared

Activity by Year

2026-2026 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersGenomics

Dan YuORCID

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Author profile →

4 papers

Recent·Most cited

Regulation of angiogenesis by signal sequence-derived peptides

Mean Ghim, Linyan Wei, Jaejoon Jung, Erlinda The, Gunjan Kukreja, Afarin Neishabouri, Azmi A. Ahmad, Muhammad Zawwad Raza, Arvene Golbazi, Keshvad Hedayatyanfard, Lei Nie, Zhengxing Zhang, Lingyun Wang, Jiasheng Zhang, Mehran M. Sadeghi

This study identifies DCBLD2 signal sequence-derived peptides that enhance VEGFR2 signaling and angiogenesis, suggesting therapeutic potential for vascular disorders.

Journal of Biological Chemistry · Aug 7, 2026Peer-reviewedCell Biology

Hidden genetic diversity in 320 nearly-complete East Asian genome assemblies

Dongya Wu, Chentao Yang, Quanyu Chen, Mingyu Suo, Feifei Zhou, Anguo Liu, Dan Yu, Lei Nie, Ting Yang, Yanqing Sun, Junmin Han, Lili Yang, Qingyang Ni, Di Sun, Yanlin Lu, , Guojie Zhang

The paper presents 320 nearly-complete East Asian genome assemblies, revealing new genetic diversity and structural variations not present in existing global pangenomes.

bioRxiv · Jul 28, 2026 · PreprintGenomics

Multidimensional variation and population stratification across 8000 complete human centromeres

Yanqing Sun, Shijie Wan, Lei Nie, Dan Yu, Feifei Zhou, Yi Yang, Xiangyu Yang, An Liu, Quanyu Chen, Kezhi Fu, Qingyang Ni, Yaoxi He, Bing Su, Yafei Mao, Kai Ye, , Wu Dongya

Over 8,000 gapless human centromeres reveal population-stratified satellite-array, inversion and haplotype variation, multiple candidate kinetochore sites in 16.8% of centromeres, and single-base substitution rates comparable to flanking pericentromeres.

bioRxiv · Jul 24, 2026 · PreprintGenomics✦ In-depth digest

Deciphering complete archaic introgression sequences in modern human genomes

Mingyu Suo, Aoyue Bi, Quanyu Chen, Dan Yu, Linghan Jiang, An Liu, Yi Yang, Hanyao Wang, Yanqing Sun, Lei Nie, Ruixue Chen, Qiangzhen Yang, Xiaotao Wang, Haishuai Wang, YongYong SHI, , Guojie Zhang

The paper introduces ASMaid, a method to detect archaic introgression sequences in human genomes, revealing more complete and diverse archaic segments than previous methods.

bioRxiv · Jul 24, 2026 · PreprintEvolutionary Biology