Bing Su

Adaptive introgression in Tibetans spans focal and distributed architectures

This study identifies Neanderthal-derived adaptive variation in Tibetans, showing functional convergence in immune and metabolic pathways, beyond the well-known EPAS1 locus.

Hidden genetic diversity in 320 nearly-complete East Asian genome assemblies

The paper presents 320 nearly-complete East Asian genome assemblies, revealing new genetic diversity and structural variations not present in existing global pangenomes.

Multidimensional variation and population stratification across 8000 complete human centromeres

Over 8,000 gapless human centromeres reveal population-stratified satellite-array, inversion and haplotype variation, multiple candidate kinetochore sites in 16.8% of centromeres, and single-base substitution rates comparable to flanking pericentromeres.

Tibetan near-complete pangenome reveals complex variants underlying high-altitude adaptation

The paper identifies novel structural variants and archaic introgressions in Tibetan genomes linked to high-altitude adaptation.

A near-complete lamprey genome illuminates ancestral vertebrate innovations

This paper presents a near-complete lamprey genome assembly, revealing gene family expansions and regulatory elements linked to vertebrate innovations.

Response to Tabin et al-Concerns about ancient DNA sequences reported from a Late Pleistocene individual from Southeast Asia

The paper responds to concerns about the reliability of ancient DNA sequences from a Late Pleistocene individual, arguing that observed patterns are better explained by aDNA damage and technical artefacts than modern contamination.

Comparative genomics of macaques and integrated insights into genetic variation and population history

This study presents genome assemblies and analyses of macaques to explore genetic variation, population history, and evolutionary differences between species and humans.

Long-Range Enhancer Networks Gradually Emerge as Key Regulators During Human Cortical Neurogenesis

The paper maps long-range enhancer networks in human, macaque, and mouse fetal cortex, showing human-specific enhancers and neuropsychiatric disorder-linked SNPs regulate gene expression during neurogenesis.

Comparative genomic analysis identifies great-ape-specific structural variants and their evolutionary significance

The paper identifies great-ape-specific structural variants and their potential role in evolutionary phenotypic innovations.

Heritability enrichment in context-specific regulatory networks improves phenotype-relevant tissue identification

SpecVar improves heritability enrichment by integrating regulatory networks with GWAS data to identify relevant tissues and shared heritability.

De novo assembly of a Tibetan genome and identification of novel structural variants associated with high altitude adaptation

The paper assembles a high-quality Tibetan genome and identifies structural variants linked to high altitude adaptation and archaic hominid ancestry.

Long-read assembly of the Chinese rhesus macaque genome and identification of ape-specific structural variants

The paper presents a high-quality long-read genome assembly of the Chinese rhesus macaque and identifies ape-specific structural variants.

Identifying Lineage-specific Targets of Darwinian Selection by a Bayesian Analysis of Genomic Polymorphisms and Divergence from Multiple Species

The paper introduces a Bayesian method to detect lineage-specific selection in multiple species and identifies new genes under selection in Hominidae evolution.

Trio deep-sequencing does not reveal unexpected mutations in Cas9-edited monkeys

The paper uses whole genome trio sequencing to assess off-target effects of Cas9 editing in monkeys and finds no unexpected mutations.