William G. Pembroke

High-throughput platforms for genetic perturbation screening using CRISPR/Cas9 in human iPSC-derived macrophages for drug discovery

The paper establishes a CRISPR/Cas9 screening platform in hiPSC-derived macrophages to identify genetic targets influencing inflammatory responses and functional phenotypes.

Conservation and divergence of vulnerability and responses to stressors between human and mouse astrocytes

The paper compares gene expression and stress responses in human and mouse astrocytes, finding conserved and divergent features that may explain differences in disease models.

Evolutionary conservation and divergence of human brain co-expression networks

The paper compares co-expression network conservation across human, mouse, and non-human primate brain data, identifying divergence patterns and disease-related genes.

The architecture of brain co-expression reveals the brain-wide basis of disease susceptibility

The paper identifies brain-wide and region-specific gene co-expression modules using RNA-seq data and links them to disease risk variants and biological processes.