Robert M. Bachoo

Glioblastoma initiation, migration, and cell types are regulated by core bHLH transcription factors ASCL1 and OLIG2

This study shows ASCL1 and OLIG2 regulate glioblastoma initiation, migration, and cell types through their dynamic interactions and target gene regulation.

pan-ECM: live brain extracellular matrix imaging with protein-reactive dye

The paper develops a method to image the entire brain extracellular matrix in live tissue using a protein-reactive dye, enabling visualization of ECM structures in various brain conditions.

Minimally invasive delivery of peptides to the spinal cord for behavior modulation

This paper presents a minimally invasive method to deliver peptides to the spinal cord for behavior modulation using optical stimulation of nanoparticles, demonstrating efficacy in inducing itching in mice without genetic modification.

Modulating the Blood-Brain Barrier by Light Stimulation of Molecular-Targeted Nanoparticles

This paper demonstrates a method to selectively open the blood-brain barrier using light-stimulated nanoparticles targeting tight junctions, enabling macromolecule and gene therapy vector delivery without neurotoxicity.

Reduction of neuronal activity mediated by blood-vessel regression in the brain

This study shows that blood vessel regression in the brain reduces neuronal activity by impairing mitochondrial metabolism and glutamate production.