David A. Weitz

This paper describes a method to generate dense neuronal microcultures by combining fibroblast reprogramming with matrix remodeling in collagen microgels.

This paper develops a microgel platform to enhance γδ T-cell expansion and function while preserving cytotoxicity and donor-specific responses.

This paper presents an implantable material platform that contains engineered bacteria to autonomously deliver therapeutics in a mouse model of prosthetic joint infection.

This paper engineers liposomes with cell membrane proteins to disrupt melanosome transfer from melanocytes to keratinocytes, offering a drug-free strategy for treating hyperpigmentation.

FilaBuster enables rapid, specific, and spatiotemporally controlled disassembly of intermediate filaments in living cells using a three-step photochemical strategy.

The paper investigates anisotropies in RNA-based biomolecular condensate interfaces, finding that purine-rich RNAs drive phase separation while pyrimidine-rich RNAs accumulate at interfaces, with distinct motion patterns observed using single-molecule imaging.

This paper engineers asymmetric lipid vesicles that enhance mRNA and protein delivery to cells, showing increased transfection efficiency and broad cargo compatibility.

This study shows that ROS-induced actin filament severing increases polymerization in vitro but can lead to network disassembly beyond a threshold.

This study shows vimentin forms liquid droplets that stabilize actin fibers by wetting them, and this behavior is observed in both a mutant and wild-type vimentin.

This study uses single molecule microscopy to show that tau condensate ageing involves liquid-solid coexistence at the fibril level, with spatial heterogeneity driving the transition.

This study shows that pancreatic ductal adenocarcinoma cells in collagen droplets form branched organoids with complex morphology, suggesting accelerated maturation compared to traditional bulk culture.

This study investigates how the fusion of biomolecular condensates, influenced by ageing and mixing rates, leads to the formation of multiphase structures with distinct material properties.

The paper examines how engrafted monocytes adapt chromatin and transcriptionally in the injured retina, showing shared and distinct features with host microglia.

This paper develops a microbial ink for 3D printing living materials using genetically engineered E. coli cells that self-assemble into nanofiber networks capable of sequestering toxins and releasing biologics.

DroNc-Seq enables high-throughput single nucleus RNA-seq analysis of archived brain tissues, demonstrating efficient and unbiased cell type classification in mouse and human samples.