Author

Nipuni M. Pannala

Purdue University West LafayetteORCID 0009-0004-5133-5043Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1

Frequent Co-Authors

Chittaranjan DasiD· 2 shared Daniel Patrick FlahertyiD· 2 shared Rishi S. PateliD· 2 shared Alisha DhimaniD· 1 shared Brittany L. Allen-PeterseniD· 1 shared Brittany N. HeiliD· 1 shared Chih-Hsuan LaiiD· 1 shared Dabin Jung· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersBiochemistry

Chittaranjan DasORCID

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2 papers

Recent·Most cited

BiochemistrybioRxivPreprintJul 16, 2026

Substrate biasing in UCHL5 proteoforms

Rishi S. Patel, Nipuni M. Pannala, Chih-Hsuan Lai…·Chittaranjan Das

This study identifies substrate biasing in UCHL5 proteoforms, showing N-terminal ubiquitination activates the enzyme toward monoubiquitin substrates and regulates debranching activity.

DOI 10.64898/2026.07.16.738907

protein structureexperimental assay

𝕏 PostBluesky

Pharmacology & ToxicologybioRxivPreprintMay 29, 2026

Identification, optimization, and structural elucidation of chloroacetamide scaffold as covalent inhibitors for Ubiquitin C-terminal Hydrolase L3

Nagabhushana C. Beeralingappa, Mengyao Lu, Rishi S. Patel…·Daniel Patrick Flaherty

This study identifies and optimizes a chloroacetamide scaffold as a covalent inhibitor for UCHL3, supported by structural and biochemical validation.

DOI 10.64898/2026.05.26.727856

experimental assaydrug response / drug discovery

𝕏 PostBluesky