Llywelyn Lee

The paper investigates the role of nitric oxide in neurovascular coupling responses in mouse cortex, finding that it mediates responses from nNOS-expressing interneurons but not sensory stimulation.

This study examines vascular function and cognitive performance in mouse models of Alzheimer's disease, atherosclerosis, and their combination, finding hemodynamic deficits in atherosclerosis mice and no differences in amyloid or plaque burden in mixed disease models.

This study shows that changes in cortical temperature modulate neurovascular coupling, with low temperatures reducing oxygen delivery and high temperatures causing vascular oscillations.

This study shows that locomotion during awake imaging alters sensory-evoked haemodynamic responses in mice, emphasizing the need to monitor movement to avoid confounding results.

This study assesses neurovascular coupling and cortical spreading depression in models of atherosclerosis and Alzheimer's disease, finding exacerbated neurovascular decline and increased amyloid-beta plaques in comorbid conditions.

The paper investigates how specific inhibitory cortical interneurons influence neurovascular coupling through optogenetic activation in mice, revealing distinct hemodynamic effects based on interneuron type.