Sascha Dehler

The paper identifies AAV variants that efficiently target adult neural stem cells in the subventricular zone, enabling genetic modification for potential regenerative therapies.

This study shows that spinal transection injury activates distant hippocampal stem cells via an immune-CNS axis, leading to increased neuron production and improved memory performance.

This study uses a mathematical model and experimental data to show that aged hippocampal NSCs remain quiescent longer and have a higher reactivation probability, which can be rescued by increased Wnt activity.