Santiago Cerrizuela

Joint recording of past and present transcriptomes reconstructs single-cell trajectories

This paper introduces scReMeMber-Seq, a method to reconstruct single-cell trajectories by linking past and present transcriptomes using methylation-based memory recording.

Single-cell triple-omics uncovers DNA methylation as key feature of stemness in the healthy and ischemic adult brain

The paper uses single-cell triple-omics to show DNA methylation patterns are key to stemness in adult brain cells, especially under ischemic conditions.

Analyzing single-cell bisulfite sequencing data with MethSCAn

The paper introduces MethSCAn, a tool for analyzing scBS data that improves methylation quantification and DMR detection, enhancing cell type discrimination with fewer cells.

Interferon regulates stem cell function at all ages by orchestrating mTOR and cell cycle

This study shows interferon regulates stem cell function across all ages by controlling mTOR and cell cycle, with beneficial effects in youth and harmful effects in aging brains.

In vivo high-throughput screening of novel adeno-associated viral capsids targeting adult neural stem cells in the subventricular zone

The paper identifies AAV variants that efficiently target adult neural stem cells in the subventricular zone, enabling genetic modification for potential regenerative therapies.