Daniel E. Goldberg

This study identifies the HLH domain of PfNCR1 as essential for its localization to narrow membrane contact sites, linking its structure to cholesterol homeostasis in Plasmodium falciparum.

This study investigates drug-drug interactions between artemisinins and quinolines in malaria treatment, finding antagonistic effects and highlighting potential liabilities in combination therapies.

This study shows that the Plasmodium heme detoxification protein (HDP) is essential for mitochondrial protein biosynthesis, not hemozoin formation, and its loss disrupts mitochondrial function and parasite survival.

This paper presents three structures of PfNCR1, a Plasmodium falciparum membrane protein, and shows it exports cholesterol to maintain membrane homeostasis, with MMV009108 inhibiting this function.

This study identifies PfHO as essential for apicoplast biogenesis and gene expression in Plasmodium falciparum, revealing its role in maintaining apicoplast-encoded RNA levels.

Whole genome sequencing reveals how Plasmodium falciparum evolves resistance to diverse compounds and identifies new antimalarial drug targets.