Pharmacology & ToxicologyACS Chemical NeurosciencePeer-reviewed
Discovery of GluA3 preferring AMPA receptor positive allosteric modulator BRD3290
Christopher Greaves, William E. Martenis, Shawn Dwayne Nelson…·Sean P. Moran
This study discovers BRD3290, a GluA3-preferring AMPA receptor PAM, but finds it does not improve cognitive function in mice despite target engagement.
DOI 10.1021/acschemneuro.6c00573