Michel Weïwer

Discovery of GluA3 preferring AMPA receptor positive allosteric modulator BRD3290

This study discovers BRD3290, a GluA3-preferring AMPA receptor PAM, but finds it does not improve cognitive function in mice despite target engagement.

The G-protein coupled receptor GPR34 maintains the homeostatic state of microglia and restrains the disease-associated microglial response in an Alzheimers disease model

This study shows that GPR34 maintains microglial homeostasis and limits disease-associated microglial responses in Alzheimer's disease models.

A foundational neuronal protein network model unifying multimodal genetic, transcriptional, and proteomic perturbations in schizophrenia.

The paper identifies three neuron-specific schizophrenia protein networks enriched for genetic and transcriptional perturbations and validates their disruption in 22q11.2 deletion carriers.