Author

Zirui Zhou

Virginia TechORCID 0000-0002-9202-2180Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 4 Research Focus:cell type annotation· 2 Assay:ChIP-seq· 2 Research Focus:differential expression· 2 Assay:DNA methylation· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 1

Frequent Co-Authors

Bohan ZhuiD· 4 shared Chang LuiD· 4 shared Lynette B. NaleriD· 3 shared Zhengzhi LiuiD· 3 shared Chengyu DengiD· 2 shared Javier González‐MaesoiD· 2 shared Qiang ZhangiD· 2 shared Alexander Murray· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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4 shared papersGenomics

Bohan ZhuORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Droplet-based bisulfite sequencing for high-throughput profiling of single-cell DNA methylomes

Qiang Zhang, Sai Ma, Zhengzhi Liu, Bohan Zhu, Zirui Zhou, Gaoshan Li, J. Javier Meana, Javier González‐Maeso, Chang Lu

This paper introduces Drop-BS, a droplet-based microfluidic method for single-cell bisulfite sequencing, enabling high-throughput DNA methylome profiling of up to 10,000 cells in 2 days.

Nature Communications · Aug 3, 2023Peer-reviewedGenomics

Epigenomic tomography for probing spatially-defined molecular state in the brain

Zhengzhi Liu, Chengyu Deng, Zirui Zhou, Ya Xiao, Shan Jiang, Bohan Zhu, Lynette B. Naler, Xiaoting Jia, Danfeng Daphne Yao, Chang Lu

This paper introduces a method to map spatial epigenomic variations in brain tissue at a centimeter scale, revealing dynamic changes in specific brain regions due to seizures.

bioRxiv · Nov 24, 2022 · PreprintGenomics

Native MOWChIP-seq: Genome-wide profiles of key protein bindings reveal functional differences among various brain regions

Zhengzhi Liu, Lynette B. Naler, Yan Zhu, Chengyu Deng, Qiang Zhang, Bohan Zhu, Zirui Zhou, Mimosa Sarma, Alexander Murray, Hehuang Xie, Chang Lu

The paper introduces native MOWChIP-seq, a low-input ChIP-seq method, and applies it to study protein binding differences between mouse brain regions.

bioRxiv · Jul 11, 2021 · PreprintGenomics

Prolonged epigenetic and synaptic plasticity alterations following single exposure to a psychedelic in mice

Mario de la Fuente Revenga, Bohan Zhu, Christopher A. Guevara, Lynette B. Naler, Justin M. Saunders, Zirui Zhou, Rudy Toneatti, Salvador Sierra, Jennifer T. Wolstenholme, Patrick M. Beardsley, George W. Huntley, Chang Lu, Javier González‐Maeso

This study shows that a single dose of the psychedelic DOI causes long-lasting epigenetic and synaptic changes in mice, linked to antidepressant effects and potential risks for psychiatric disorders.

bioRxiv · Feb 24, 2021 · PreprintNeuroscience