Małgorzata Wygrecka

Cell-specific FUS loss enhances ageing-associated transcriptional elongation in lung fibrosis

The paper investigates how FUS loss in fibroblasts affects transcriptional elongation and senescence in IPF, finding that reduced FUS levels increase Pol II activity and fibrosis-related gene expression.

Adventitial fibroblasts direct smooth muscle cell-state transition in pulmonary vascular disease

The paper identifies disease-associated states in PASMC and PAAF from IPAH patients and identifies potential modulators of PASMC phenotypic transition.

Positioning of nucleosomes containing γ-H2AXprecedes active DNA demethylation and transcription initiation

The paper shows that HMGA2 induces DNA nicks required for nucleosome incorporation containing H2A.X, which is necessary for DNA demethylation and transcription initiation.