Author

Ali Ghoochani

Aligning Science Across Parkinson'sORCID 0000-0002-5352-0072Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Assay:metabolomics· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Monther Abu-RemailehiD· 2 shared Natalia Gomez‐OspinaiD· 2 shared Alessandro OriiD· 1 shared Alina IsakovaiD· 1 shared Angela Schulz· 1 shared Anish Alur· 1 shared Chetan Chilkunda· 1 shared Christian FrankeiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersBiochemistry

Monther Abu-RemailehORCID

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2 papers

Recent·Most cited

The Batten disease gene product CLN6 is a glycerophosphoglycerol epimerase that establishes S,S-BMP stereochemistry

Zhijun Zhu, Jian Xiong, Ibrahim B Maaz, Matthew J. Matrongolo, Ali Ghoochani, Chetan Chilkunda, Xuejun Peng, Anish Alur, Christian Porsen, Angela Schulz, Susan Cotman, Natalia Gomez‐Ospina, Monther Abu-Remaileh

This study identifies CLN6 as a glycerophosphoglycerol epimerase that converts R,S-GPG to S,S-GPG, establishing the S,S-BMP stereochemistry critical for lysosomal function.

bioRxiv · Oct 9, 2026 · PreprintBiochemistry

Cell-Type Resolved Protein Atlas of Brain Lysosomes Identifies SLC45A1-Associated Disease as a Lysosomal Disorder

Ali Ghoochani, Julia C. Heiby, Eshaan S. Rawat, Uche N. Medoh, Domenico Di Fraia, Wentao Dong, Marc Gastou, Mohit Rastogi, Vincent Hernandez, Kwamina Nyame, Nouf N. Laqtom, William Durso, Christina Valkova, Alina Isakova, Christoph Kaether, , Monther Abu-Remaileh

The paper creates a cell-type-specific lysosome protein atlas in the brain, identifies SLC45A1 as a neuron-specific lysosomal protein, and shows its role in lysosomal function and neurodegeneration.

Cell · Jan 22, 2026Peer-reviewedCell Biology