Timothy Grant

This paper improves cryo-EM reconstruction of small complexes using 2D template matching and high-resolution structures as priors, enhancing density of ligand-binding sites in a 43 kDa protein kinase.

This study identifies a shark-derived VNAR that binds a hidden epitope on FAP, revealing structural insights for multiepitope targeting strategies.

This study shows that LEA proteins can reduce orientation bias and improve particle-orientation distributions in cryo-EM by mitigating air-water interface damage.

The paper presents two primosome structures in Escherichia coli, revealing mechanisms of DNA replication restart and a similarity between DnaT and DnaA.

The paper presents a comprehensive atlas of lysine acetylation in the mouse, identifying 17,952 sites across 15 tissues and highlighting shared and tissue-specific acetylation events.

This paper introduces BPHON, a method that uses image analysis to score the fitness of protein structures against NMR spectra without requiring full resonance assignments.

This paper introduces ANSA, an automated NMR spectral alignment tool using cryo-EM motion correction, improving alignment accuracy and reducing manual effort in NMR data processing.

The paper introduces SPOT-RASTR, a cryo-EM technique using lipid nanotubes to overcome air-water interface and preferred orientation issues, enabling automated data collection and near-atomic resolution.

This paper introduces a modified mass spectrometry system for depositing gas-phase protein complexes onto EM grids, enabling 3D structure determination of non-covalent protein complexes like GroEL.

The paper determines the in situ structure of rotavirus VP1 RNA-dependent RNA polymerase using local reconstruction, showing conformational changes during transcription and stochastic distribution of VP1 molecules.