Sofia Gonzalez-Nolde

This study identifies PIEZO1 as a critical mediator of myofibroblast activation and fibrosis in post-traumatic osteoarthritis through mechanosensing mechanisms.

This study shows that TSP2 deficiency leads to increased joint inflammation and worsened osteoarthritis after injury, suggesting TSP2's role in joint homeostasis.

The paper introduces a standardized, open-source protocol for noninvasive joint injury in mice, resulting in post-traumatic osteoarthritis, and provides tools for reproducibility and analysis.

This study shows CXCL16 drives synovial inflammation and joint pain through CXCR6, suggesting it as a target for treating post-traumatic osteoarthritis.