Cancer BiologybioRxivPreprint
Loss of CARM1 alters the developmental programming of Glioma stem-like cells and creates a druggable NGFR/NTRK dependency
Dejauwne L. Young, Jennifer T. Aguilan, Ronald R. Cutler…·Simone Sidoli
This study shows that CARM1 loss in GSCs disrupts developmental programming, shifts lineage towards radial glia, and creates a dependency on NGFR/NTRK signaling, making them vulnerable to NTRK inhibitors.
DOI 10.1101/2025.04.11.647869