Brittany A Lende-Dorn

This study develops high-titer lentiviral vectors for RNA-based gene circuits by optimizing gene syntax and genetic parts to enhance vector production and expression.

DIAL is a framework for designing synthetic promoters that generate heritable, tunable gene expression setpoints across cell types.

This study shows that optimal MAPK signaling levels enhance direct conversion of fibroblasts to motor neurons, while excessive levels induce senescence and reduce conversion rates.

This paper introduces RE array plasmids and the CTRL method to control gene expression by sequestering transcription factors in mammalian cells.

This study identifies proliferation history and transcription factor levels as key drivers of direct conversion of fibroblasts to motor neurons using a synthetic biology approach.