Takafumi Toyohara

This paper develops a human vascular model using iPSC-derived cells that mimics vascular aging phenotypes and responds to vasoactive stimuli, showing potential for aging research and drug discovery.

This paper shows that MA-5 improves hearing loss and extends lifespan in mice by increasing NAD+ and SIRT1 through DNA-PK activation and mitochondrial function.

The paper identifies a drug combination targeting human POMC neurons to reduce food intake and body weight using hPSC-derived neurons and mouse models.

This study identifies mitochondrial dysfunction in sporadic inclusion body myositis and shows that MA-5 improves mitochondrial function and protects myoblasts.