Joseph Rainaldi

This paper introduces MATCH, a method to engineer AAV tropism by conjugating targeting proteins, achieving efficient transduction of T cells and enhanced brain delivery in vivo.

The paper introduces OASIS, a method to screen soluble ligands by enforcing autocrine signaling, and applies it to identify self-renewal factors in hiPSCs.

This study identifies serine dehydratase (Sds) as a regulator of serine and sphingolipid metabolism, showing that its deletion improves skin repair in diabetic mice.

This paper develops a novel U7 snRNA scaffold that significantly enhances ADAR-mediated RNA base editing in vitro and in vivo, achieving up to 76% editing efficiency in mouse models.