Duncan S. Sutherland

Thymic Treg-derived T follicular regulatory cells prevent catastrophic humoral autoimmunity in response to TLR7-driven inflammation

This study shows that thymic Treg-derived T follicular regulatory cells prevent autoimmunity by limiting GC responses during TLR7-driven inflammation.

Serial intravital microscopy reveals temporal dynamics of autoreactive germinal centers in the spleen

This study uses intravital microscopy to track autoreactive germinal centers in the spleen of live mice over weeks, revealing their dynamic expansion and contraction.

Display of clustered antigen by follicular dendritic cells tunes B-cell receptor activation

The paper shows that antigen clustering on follicular dendritic cells enhances B-cell receptor activation through geometric control of tyrosine phosphatase exclusion.

Nanoscale precise stamping of biomolecule patterns using DNA origami

This paper introduces a DNA origami stamping technique for precise nanoscale biomolecule patterning, validated using DNA-PAINT microscopy to assess efficiency and resolution.

Familial Alzheimer disease mutation identifies novel role of SORLA in release of neurotrophic exosomes

This study identifies a novel role for SORLA in regulating exosome release and neurotrophic function, linking SORL1 mutations to Alzheimer's disease pathology.