Molecular BiologybioRxivPreprint
A high-impact COL6A3 mutation alters the response of chondrocytes in neo-cartilage organoids to hyper-physiologic mechanical loading
Niek G.C. Bloks, Zainab Harissa, Shaunak Sanjay Adkar…·Ingrid Meulenbelt
This paper investigates how a COL6A3 mutation affects chondrocyte response to mechanical stress in a human iPSC-derived cartilage organoid model, finding reduced PCM protein binding and impaired stress response.
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