Author

Nancy S. Steward

Washington University in St. Louis

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Bioengineering· 1 Developmental Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 3 Organism:human· 3 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Farshid GuilakiD· 3 shared Alireza SavadipouriD· 2 shared Amanda R. DicksiD· 2 shared Ruhang TangiD· 2 shared Zainab HarissaiD· 2 shared Aat A. MulderiD· 1 shared Berend B.R. de Koning· 1 shared Chia‐Lung WuiD· 1 shared

Activity by Year

2022-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersBioengineering

Farshid GuilakORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

PIEZO1-Mediated Mechanotransduction Regulates Collagen Synthesis on Nanostructured 2D and 3D Models of Fibrosis

Neda Rashidi, Natalia S. Harasymowicz, Alireza Savadipour, Nancy S. Steward, Ruhang Tang, Sara J. Oswald, Farshid Guilak

This study shows PIEZO1 regulates collagen synthesis in hASCs based on substrate architecture, with YAP/TAZ translocation and collagen production being independent outcomes of PIEZO1 activation.

Acta Biomaterialia · Dec 13, 2024Peer-reviewedBioengineering

Skeletal dysplasia-causing TRPV4 mutations suppress the hypertrophic differentiation of human iPSC-derived chondrocytes

Amanda R. Dicks, Grigory I. Maksaev, Zainab Harissa, Alireza Savadipour, Ruhang Tang, Nancy S. Steward, Wolfgang Liedtke, Colin G. Nichols, Chia‐Lung Wu, Farshid Guilak

This study investigates how TRPV4 mutations affect chondrocyte differentiation and identifies altered BMP signaling as a mechanism for skeletal dysplasia.

eLife · Feb 13, 2023Peer-reviewedDevelopmental Biology

A high-impact COL6A3 mutation alters the response of chondrocytes in neo-cartilage organoids to hyper-physiologic mechanical loading

Niek G.C. Bloks, Zainab Harissa, Shaunak Sanjay Adkar, Amanda R. Dicks, Ghazaleh Hajmousa, Nancy S. Steward, Roman I. Koning, Aat A. Mulder, Berend B.R. de Koning, M. Kloppenburg, Rodrigo Coutinho de Almeida, Y.F. Ramos, Farshid Guilak, Ingrid Meulenbelt

This paper investigates how a COL6A3 mutation affects chondrocyte response to mechanical stress in a human iPSC-derived cartilage organoid model, finding reduced PCM protein binding and impaired stress response.

bioRxiv · Dec 19, 2022 · PreprintMolecular Biology