Author

Amanda R. Dicks

Washington University in St. LouisORCID 0000-0002-6036-280XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Developmental Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Approach:statistical model· 1

Frequent Co-Authors

Farshid GuilakiD· 2 shared Nancy S. Steward· 2 shared Zainab HarissaiD· 2 shared Aat A. MulderiD· 1 shared Alireza SavadipouriD· 1 shared Berend B.R. de Koning· 1 shared Chia‐Lung WuiD· 1 shared Colin G. NicholsiD· 1 shared

Activity by Year

2022-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersDevelopmental Biology

Farshid GuilakORCID

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2 papers

Recent·Most cited

Skeletal dysplasia-causing TRPV4 mutations suppress the hypertrophic differentiation of human iPSC-derived chondrocytes

Amanda R. Dicks, Grigory I. Maksaev, Zainab Harissa, Alireza Savadipour, Ruhang Tang, Nancy S. Steward, Wolfgang Liedtke, Colin G. Nichols, Chia‐Lung Wu, Farshid Guilak

This study investigates how TRPV4 mutations affect chondrocyte differentiation and identifies altered BMP signaling as a mechanism for skeletal dysplasia.

eLife · Feb 13, 2023Peer-reviewedDevelopmental Biology

A high-impact COL6A3 mutation alters the response of chondrocytes in neo-cartilage organoids to hyper-physiologic mechanical loading

Niek G.C. Bloks, Zainab Harissa, Shaunak Sanjay Adkar, Amanda R. Dicks, Ghazaleh Hajmousa, Nancy S. Steward, Roman I. Koning, Aat A. Mulder, Berend B.R. de Koning, M. Kloppenburg, Rodrigo Coutinho de Almeida, Y.F. Ramos, Farshid Guilak, Ingrid Meulenbelt

This paper investigates how a COL6A3 mutation affects chondrocyte response to mechanical stress in a human iPSC-derived cartilage organoid model, finding reduced PCM protein binding and impaired stress response.

bioRxiv · Dec 19, 2022 · PreprintMolecular Biology