Author

M. Kloppenburg

Leiden University Medical CenterORCID 0000-0002-9294-2307Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetic & Genomic Medicine· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:experimental assay· 1 Research Focus:GWAS / association mapping· 1 Assay:GWAS summary statistics· 1 Approach:statistical model· 1

Frequent Co-Authors

Ingrid MeulenbeltiD· 2 shared Rodrigo Coutinho de AlmeidaiD· 2 shared Aat A. MulderiD· 1 shared Almut LuetgeiD· 1 shared Amanda R. DicksiD· 1 shared Ana Maria ValdesiD· 1 shared André Gerardus UitterlindeniD· 1 shared Andrei BarysenkaiD· 1 shared

Activity by Year

2021-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersMolecular Biology

Ingrid MeulenbeltORCID

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2 papers

Recent·Most cited

A high-impact COL6A3 mutation alters the response of chondrocytes in neo-cartilage organoids to hyper-physiologic mechanical loading

Niek G.C. Bloks, Zainab Harissa, Shaunak Sanjay Adkar, Amanda R. Dicks, Ghazaleh Hajmousa, Nancy S. Steward, Roman I. Koning, Aat A. Mulder, Berend B.R. de Koning, M. Kloppenburg, Rodrigo Coutinho de Almeida, Y.F. Ramos, Farshid Guilak, Ingrid Meulenbelt

This paper investigates how a COL6A3 mutation affects chondrocyte response to mechanical stress in a human iPSC-derived cartilage organoid model, finding reduced PCM protein binding and impaired stress response.

bioRxiv · Dec 19, 2022 · PreprintMolecular Biology

Using multivariable Mendelian randomization to estimate the causal effect of bone mineral density on osteoarthritis risk, independent of body mass index

April E. Hartley, Eleanor C. M. Sanderson, Raquel Granell, Lavinia Paternoster, Jie Zheng, George Davey Smith, Lorraine Southam, Konstantinos Hatzikotoulas, Cindy Germaine Boer, Joyce B. J. van Meurs, Eleftheria Zeggini, Lilja Stefánsdóttir, Yanfei Zhang, Rodrigo Coutinho de Almeida, Tian T. Wu, , Jonathan H. Tobias

This study uses multivariable Mendelian randomization to show that higher bone mineral density causally increases osteoarthritis risk independently of body mass index.

International Journal of Epidemiology · Nov 15, 2021Peer-reviewedGenetic & Genomic Medicine