Yaser Hashem

This study provides high-resolution structural insights into the maturation and translation processes of a flowering plant mitoribosome using cryo-electron microscopy and nanopore sequencing.

This paper introduces RAPPL, a rapid, simple, and cost-effective method for isolating ribosomes and translational machinery, demonstrating its utility in functional and structural studies across various species and sample types.

The paper identifies inconsistencies in rabbit ribosomal rRNA sequences and proposes using the Broad Institute's genome sequence to standardize numbering and improve model consistency.

This study characterizes the mitoribosome structure and function in Chlamydomonas reinhardtii, revealing its unique RNA assembly, protein components, and membrane attachment mechanisms.

The paper shows that the Halastavi arva virus IGR IRES initiates translation without initiation factors or an AUG codon by directly placing the first codon in the decoding center.

The paper determines the structure of the 43S PIC from Trypanosoma cruzi and identifies structural differences in translation initiation compared to mammalian hosts.

The paper reports cryo-EM structures of plant mitochondrial complex I, revealing a plant-specific carbonic anhydrase domain and its role in complex stability.

This study provides structural and functional evidence that NusG links transcription and translation in E. coli by binding both RNA polymerase and the ribosome.

The paper presents cryo-EM structures of mature and intermediate mitoribosomes from Leishmania tarentolae and Trypanosoma cruzi, revealing the structure and maturation of the large subunit ribosomal RNA and associated maturation factors.

This study presents a near-atomic resolution cryo-EM structure of the plant mitochondrial ribosome from cauliflower, revealing unique rRNA expansion segments and their interactions with PPR proteins.

The paper presents cryo-EM structures of mammalian late-stage 48S initiation complexes with different mRNA sequences, revealing mRNA-eIF interactions and the structural role of ABCE1.