Author

Angelita Simonetti

Centre National de la Recherche ScientifiqueORCID 0000-0001-7983-4945Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 3 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Assay:electronic health records· 1 Organism:human· 1 Approach:matrix factorization· 1

Frequent Co-Authors

Anthony BochleriD· 3 shared Yaser HashemiD· 3 shared Heddy SoufariiD· 2 shared Lauriane KühniD· 2 shared A. R. RibeiroiD· 1 shared Alexandre R. Haller· 1 shared Antonin LallementiD· 1 shared Chadia Nahy· 1 shared

Activity by Year

2020-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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3 shared papersMolecular Biology

Anthony BochlerORCID

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Author profile →

4 papers

Recent·Most cited

Interaction of lncRNA LENT with DHX36 regulates translation and suppresses autophagy in melanoma.

Alexandre R. Haller, Giovanni Gambi, Mattia D’Agostino, Guillaume Davidson, Antonin Lallement, Gabrielle Mengus, Chadia Nahy, Nadia Messaddeq, Guillaume Bec, Angelita Simonetti, Eric Ennifar, Irwin Davidson

This study identifies LENT, a lncRNA regulated by MITF, which interacts with DHX36 to modulate translation and suppress autophagy in melanoma cells.

Cell Death and Disease · Dec 19, 2025Peer-reviewedCancer Biology

The Halastavi arva virus intergenic region IRES promotes translation by the simplest possible initiation mechanism

Irina S. Abaeva, Quentin Vicens, Anthony Bochler, Heddy Soufari, Angelita Simonetti, Tatyana V. Pestova, Yaser Hashem, Christopher U.T. Hellen

The paper shows that the Halastavi arva virus IGR IRES initiates translation without initiation factors or an AUG codon by directly placing the first codon in the decoding center.

Cell Reports · Dec 1, 2020Peer-reviewedMolecular Biology

Structural differences in translation initiation between pathogenic trypanosomatids and their mammalian hosts

Anthony Bochler, Jailson Brito Querido, Terezie Prilepskaja, Heddy Soufari, Angelita Simonetti, Mayara Lúcia Del Cistia, Lauriane Kühn, A. R. Ribeiro, Leoš Shivaya Valášek, Yaser Hashem

The paper determines the structure of the 43S PIC from Trypanosoma cruzi and identifies structural differences in translation initiation compared to mammalian hosts.

Cell Reports · Dec 1, 2020Peer-reviewedMolecular Biology

Structural insights into the mammalian late-stage initiation complexes

Angelita Simonetti, Ewelina Guca, Anthony Bochler, Lauriane Kühn, Yaser Hashem

The paper presents cryo-EM structures of mammalian late-stage 48S initiation complexes with different mRNA sequences, revealing mRNA-eIF interactions and the structural role of ABCE1.

Cell Reports · Apr 1, 2020Peer-reviewedMolecular Biology