Enhanced TRPV1 activation through TLR-4 and PKA signaling in Dorsal Root Ganglia Neurons
Júlia Borges Paes Lemes, Kauê Franco Malange, Alisa Panichkina, Juliana Maria Navia Pelaez, Soo‐Ho Choi, Maksim Dolmat, Gilson Gonçalves dos Santos, Sara Anna Dochnal, Maripat Corr, Yury I. Miller, Tony L. Yaksh
This study shows that TLR-4 enhances TRPV1-mediated calcium influx in DRG neurons through PKA signaling, contributing to pain hypersensitivity.
bioRxiv · Jun 29, 2026 · PreprintPharmacology & Toxicology