Ramesh Palaniswamy

This study identifies two distinct subgroups of 16p11.2 deletion mice with different seizure susceptibility, circuit activity, brain structure, and gene expression profiles.

The paper maps cell type densities in the mouse brain using single-cell imaging and computational analysis, revealing sex differences, shared signatures among brain regions, and associations between cell densities and anatomical functions.

The paper quantifies whole-brain XCI at single-cell resolution and finds a 60:40 paternal-to-maternal inactivation ratio that reduces disease penetrance in Fragile-X models.

The paper provides a detailed cellular-resolution map of the mouse primary motor cortex, defining cell types and their connectivity.

The paper develops genetic tools to dissect glutamatergic neuron subpopulations and their developmental trajectories in the cerebral cortex.