Pavel Osten

Genetic and stochastic basis of phenotypic discordance in 16p11.2 mouse model deletion

This study identifies two distinct subgroups of 16p11.2 deletion mice with different seizure susceptibility, circuit activity, brain structure, and gene expression profiles.

Converging pathways: shared brain circuitry engaged by monoaminergic antidepressants, ketamine and psilocybin

This study compares brain activity induced by monoaminergic antidepressants, ketamine, and psilocybin in mice, revealing shared limbic circuits and differences in timing of effects.

A Comprehensive Atlas of Cell Type Density Patterns and Their Role in Brain Organization

The paper maps cell type densities in the mouse brain using single-cell imaging and computational analysis, revealing sex differences, shared signatures among brain regions, and associations between cell densities and anatomical functions.

Sexual coordination in a whole-brain map of prairie vole pair bonding

The paper identifies brain circuits involved in prairie vole pair bonding using whole-brain mapping and finds that bonding-related circuits are largely sexually monomorphic and show coordinated activity between pair members.

A circuit from the locus coeruleus to the anterior cingulate cortex modulates offspring interactions in mice

The paper identifies a sex-dependent neural circuit from the locus coeruleus to the anterior cingulate cortex that modulates parental care in mice by influencing pup retrieval behavior.

High-throughput confocal airy beam oblique light-sheet tomography of brain-wide imaging at single-cell resolution

Building functional circuits in multispecies brains.

This study uses interspecies neural blastocyst complementation to build and test functional rat-mouse neural circuits in rat-mouse brains, showing synaptic activity and partial behavioral rescue.

The cellular architecture of microvessels, pericytes and neuronal cell types in organizing regional brain energy homeostasis in mice

The paper maps the spatial relationship between cerebrovasculature, pericytes, and neuronal cell types in mice to reveal how they support regional brain energy homeostasis.

Brain X chromosome inactivation is not random and can protect from paternally inherited neurodevelopmental disease.

The paper quantifies whole-brain XCI at single-cell resolution and finds a 60:40 paternal-to-maternal inactivation ratio that reduces disease penetrance in Fragile-X models.

A multimodal cell census and atlas of the mammalian primary motor cortex

The paper generates a multimodal cell census and atlas of the mammalian primary motor cortex, revealing a unified molecular genetic landscape and cross-species taxonomy of cell types.

Cellular Anatomy of the Mouse Primary Motor Cortex

The paper provides a detailed cellular-resolution map of the mouse primary motor cortex, defining cell types and their connectivity.

Social isolation uncovers a brain-wide circuit underlying context-dependent territory-covering micturition behavior

The paper identifies a brain-wide circuit that modulates micturition behavior based on social and sensory contexts in mice.

Super-resolution light-sheet fluorescence microscopy by SOFI.

The paper introduces LS-SOFI, a method combining light-sheet fluorescence microscopy and super-resolution optical fluctuation imaging for fast nanoscale-resolution imaging in 3D tissues.

Genetic dissection of glutamatergic neuron subpopulations and developmental trajectories in the cerebral cortex

The paper develops genetic tools to dissect glutamatergic neuron subpopulations and their developmental trajectories in the cerebral cortex.

Distinct Cortical-Thalamic-Striatal Circuits Through the Parafascicular Nucleus

The paper identifies distinct cortical-thalamic-striatal circuits within the parafascicular nucleus in mice, revealing heterogeneous neurons organized into parallel functional subcircuits.

Radial glial lineage progression and differential intermediate progenitor amplification underlie striatal compartments and circuit organization

This study identifies lineage programs in radial glial progenitors that generate striosome and matrix compartments through distinct intermediate progenitors, revealing their role in striatal circuit organization.

Oblique light-sheet tomography: fast and high resolution volumetric imaging of mouse brains

This paper introduces a new light-sheet microscopy technique for high-resolution volumetric imaging of whole mouse brains.