Joseph E. Knox

Endogenous pathology in tauopathy mice progresses via brain networks

The paper uses whole-brain imaging to show that tau pathology in mice propagates retrogradely through brain networks.

Brain X chromosome inactivation is not random and can protect from paternally inherited neurodevelopmental disease.

The paper quantifies whole-brain XCI at single-cell resolution and finds a 60:40 paternal-to-maternal inactivation ratio that reduces disease penetrance in Fragile-X models.

Regional, layer, and cell-class specific connectivity of the mouse default mode network

This study identifies the anatomical composition and connectivity patterns of the mouse default mode network at the regional, layer, and cell-class levels.

The organization of intracortical connections by layer and cell class in the mouse brain

The paper expands the Allen Mouse Brain Connectivity Atlas by analyzing intracortical connections at the layer and cell class level, revealing modular organization and distinct projection patterns.

Whole brain imaging reveals distinct spatial patterns of amyloid beta deposition in three mouse models of Alzheimer’s disease

The paper uses whole brain imaging to compare amyloid beta deposition patterns in three Alzheimer's disease mouse models, revealing distinct spatial distributions across brain regions.

High resolution data-driven model of the mouse connectome

The paper constructs a high-resolution voxel-scale model of the mouse connectome using anterograde tracing data, outperforming previous regional models.