Thomas Neil Williams

The paper identifies African-specific genetic loci associated with iron status and risk of severe malaria and bacteremia in children, highlighting limited transferability of European polygenic risk scores.

The paper investigates how geographical variation influences the adaptive evolution of Plasmodium falciparum mutations that counteract sickle cell trait protection.

The paper identifies a novel genetic locus OSBPL11 associated with vitamin D levels and cardiometabolic health in African populations through genome-wide analysis.

The paper genotypes PIEZO1 STR alleles in malaria cases and controls, finding a modest protective effect of E756del against malaria.

The paper investigates how non-O ABO blood group genotypes relate to Plasmodium falciparum rosetting and severe malaria risk in Kenyan children.

The paper investigates the association between host sickle cell haemoglobin and parasite genetic variation in malaria severity, finding that parasite alleles linked to HbS show strong linkage disequilibrium and frequency covariation with HbS.

The paper improves statistical power in severe malaria genetic studies by addressing phenotypic imprecision through a probabilistic diagnostic model and data-tilting approach.

The paper shows that Dantu blood group variant increases red blood cell tension, reducing Plasmodium falciparum invasion and protecting against severe malaria.

This study identifies five genome-wide associations with severe malaria risk in 17,000 individuals from Africa, Asia, and Oceania, including a new variant linked to cerebral malaria.

The paper uses ancient DNA analysis to show that Papuan ancestry arrived in Vanuatu around 2400 BP, suggesting multiple waves of migration from Near Oceania.

The paper identifies a structural variant in GYPA and GYPB genes associated with reduced risk of severe malaria in sub-Saharan African populations.