J. Alexandra Rowe

CRISPR/Cas9 genome editing to generate single variant Plasmodium falciparum lines and enable reverse genetic studies of PfEMP1 function in live parasites

Identification of novel PfEMP1 variants containing domain cassettes 11, 15 and 8 that mediate the Plasmodium falciparum virulence-associated rosetting phenotype

The paper identifies novel PfEMP1 variants associated with rosetting in Plasmodium falciparum, expanding the known types of PfEMP1 that mediate this phenotype.

Alignment of multiple metabolomics LC-MS datasets from disparate diseases to reveal fever-associated metabolites

This study aligns metabolomics LC-MS datasets from malaria, leishmaniasis, and Zika virus to identify fever-associated metabolites, finding the kynurenine pathway as most affected.

Non-O ABO blood group genotypes differ in their associations with Plasmodium falciparum rosetting and severe malaria

The paper investigates how non-O ABO blood group genotypes relate to Plasmodium falciparum rosetting and severe malaria risk in Kenyan children.

Red blood cell tension controls Plasmodium falciparum invasion and protects against severe malaria in the Dantu blood group

The paper shows that Dantu blood group variant increases red blood cell tension, reducing Plasmodium falciparum invasion and protecting against severe malaria.