Xiao Liu

The paper identifies distinct cytokine signaling networks in mouse models of arthritis that mirror human RA synovial pathotypes, revealing molecular mechanisms underlying disease heterogeneity.

The paper introduces tFold-TCR, a model for predicting TCR-pMHC structures, achieving higher accuracy and speed than existing methods and creating a large database of these structures.

The paper identifies CRTAM-expressing CD4+ T-cells in lymphoid-driven synovitis and shows that IL-6 and IL-27 inhibit their activation through STAT3 and ZEB1.

The paper introduces immuneREF, a method to quantify immune repertoire similarity across health and disease, finding that healthy and diseased repertoires are more similar than previously thought.

This study identifies six new genetic variants associated with major adverse cardiovascular events in ACS patients on dual antiplatelet therapy and develops a predictive classifier for MACE.

This paper performs M-GWAS on a Chinese cohort to identify genetic contributions to the gut microbiome and its associations with complex diseases.

The paper integrates GWAS data with functional genomic annotations of decidual stromal cells to identify loci and target genes associated with gestational duration and preterm birth.

LFMD improves low-frequency mutation detection in high-depth sequencing by combining duplex sequencing and bottleneck sequencing to enhance sensitivity and specificity.

This paper introduces stLFR, a low-cost method for long DNA sequencing that enables accurate variant calling, haplotyping, and de novo assembly.

The paper presents a single-cell transcriptomic analysis of nucleated cells in umbilical cord blood, identifying cell types, subpopulations, and transcriptional programs that may impact transplant outcomes.

The paper shows that skin pigmentation in African populations, particularly the KhoeSan, is highly heritable and polygenic, with many new genetic loci identified beyond previously known ones.