Martine Darwish

The paper identifies coordinated neoantigen-specific CD8 T cell responses as key predictors of PD-(L)1 therapy efficacy in non-small cell lung cancer patients.

The paper investigates how immunodominance affects CD8+ T cell differentiation and hierarchy after RNA vaccination, finding that dominant responses influence subdominant ones through cross-competition.

This paper evaluates machine learning approaches for predicting T-cell receptor specificity, highlighting limitations in current data and methods, and proposes a new framework integrating biophysical measurements.