Joyce H. Lee

A transcriptional biosensor reveals mechanisms of α-ketoglutarate signaling to chromatin

The paper develops a biosensor to monitor α-ketoglutarate in human cells and identifies a mitochondrial-to-nuclear pathway regulating chromatin methylation.

Bispecific Targeting of CHI3L1 and PD-1/PD-L1 Axis as a Novel Therapeutic Strategy for Idiopathic Pulmonary Fibrosis

This study identifies a stimulatory interaction between CHI3L1 and the PD-1/PD-L1 axis in pulmonary fibrosis and shows that bispecific targeting of both reduces fibrosis in mice.

Kasugamycin inhibits melanoma lung metastasis and regulates CHI3L1-driven M2-like tumor-associated macrophage differentiation