Javier Egea

This study shows that NCLX is necessary for HIF-1 stabilization and transcriptional activity during hypoxia, linking acute and medium-term hypoxic responses through mitochondrial signaling.

This study shows that NLRP3 inhibition after reperfusion reduces brain injury in ischemia by protecting the blood-brain barrier and reducing inflammation.

This study shows that TLR4-pathway activation in astrocytes after TBI leads to synaptic loss and BBB damage, which can be mitigated by TLR4 inhibition.

This study identifies NOX5 as a key mediator of calcium-dependent reactive oxygen species formation and blood-brain barrier breakdown after reperfusion in stroke, suggesting NOX inhibition as a potential therapeutic strategy.