Yoichi Araki

CRISPR-mediated transcriptional activation as a mutation-independent therapeutic strategy for SYNGAP1-related intellectual disability

This paper demonstrates that CRISPR-mediated transcriptional activation can upregulate SYNGAP1 in a mouse model of SRID and human neurons, rescuing deficits without targeting mutations.

Context-dependent hyperactivity in syngap1a and syngap1b zebrafish autism models.

This study generates zebrafish models of SYNGAP1 disorder and shows that syngap1ab mutants exhibit context-dependent hyperactivity linked to altered arousal states.

Mouse models of SYNGAP1-related intellectual disability

This paper generates two knock-in mouse models with human SYNGAP1 mutations causing intellectual disability, showing reduced protein levels and recapitulating key disease features.

SynGAP regulates synaptic plasticity and cognition independent of its catalytic activity

This study shows SynGAP regulates synaptic plasticity and cognition through phase separation, not its catalytic activity.

Endogenous Syngap1 Alpha Splice Forms Promote Cognitive Function and Seizure Protection

The paper shows that specific SynGAP splice variants improve cognitive function and reduce seizures in mice.

SynGAP splice isoforms differentially regulate synaptic plasticity and dendritic development

This study shows that different SynGAP splice variants have distinct roles in synaptic plasticity and dendritic development through unique spatiotemporal expression and phase separation properties.

SynGAP Splice Variants Display Heterogeneous Spatio-Temporal Expression And Subcellular Distribution In The Developing Mammalian Brain

The paper investigates SynGAP splice variants' spatio-temporal expression and subcellular distribution in the developing mammalian brain, finding isoform-specific patterns and localization changes.

Splicing of the SynGAP Carboxyl-Terminus Enables Isoform-Specific Tuning of NMDA Receptor Signaling Linked to Cognitive Function

The paper investigates how the SynGAP-1 PBM regulates NMDA receptor signaling and cognitive function in mice, finding that disrupting the PBM leads to synaptic and cognitive impairments.

Low-dose Perampanel rescues cortical gamma dysregulation associated with parvalbumin interneuron GluA2 upregulation in epileptic Syngap1+/- mice

The paper identifies GluA2 upregulation in parvalbumin interneurons as a cause of gamma dysregulation in Syngap1+/- mice and shows that Perampanel rescues this dysfunction.