Loïs S. Miraucourt

The paper maps molecular features of human spinal cord dorsal and ventral horns, identifying neuronal types and sex-specific glial differences using single-nucleus sequencing and spatial transcriptomics.

ElecFeX provides a user-friendly MATLAB-based toolkit for efficient feature extraction from single-cell electrophysiological recordings, enabling streamlined analysis of large datasets.

This study identifies a calcium-dependent mechanism that modulates spinal dorsal horn PVINs' electrical activity after nerve injury, showing that impaired calcium buffering increases SK channel activity and reduces intrinsic excitability.

This study shows that parvalbumin protein (PVp) buffers calcium to maintain tonic firing in PV neurons, and its reduction after nerve injury leads to mechanical allodynia.