Author

Mitsuo Oshimura

Chromosome Engineering Research Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Organism:rat· 1

Frequent Co-Authors

Anna J. MoyeriD· 3 shared Roger H. ReevesiD· 3 shared Yasuhiro KazukiiD· 3 shared Kanako KazukiiD· 2 shared Nandini SinghiD· 2 shared Naohiro NodaiD· 2 shared Naoyo Kajitani· 2 shared Satoko MatsukuraiD· 2 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersGenetics

Anna J. MoyerORCID

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Author profile →

3 papers

Recent·Most cited

Overexpression screen of chromosome 21 genes reveals modulators of Sonic hedgehog signaling relevant to Down syndrome

Anna J. Moyer, Fabian‐Xosé Fernandez, Yicong Li, Donna K. Klinedinst, Liliana Florea, Yasuhiro Kazuki, Mitsuo Oshimura, Roger H. Reeves

The paper identifies multiple chromosome 21 genes that modulate Sonic hedgehog signaling, which is dysregulated in Down syndrome.

Disease Models & Mechanisms · Mar 30, 2023Peer-reviewedGenetics

The first transchromosomic rat model with human chromosome 21 shows robust Down syndrome features

Yasuhiro Kazuki, Feng Gao, Miho Yoshida Yamakawa, Masumi Hirabayashi, Kanako Kazuki, Naoyo Kajitani, Sachiko Miyagawa‐Tomita, Satoshi Abe, Makoto Sanbo, Hiromasa Hara, Hiroshi Kuniishi, Satoshi Ichisaka, Yoshio Hata, Moeka Koshima, Haruka Takayama, , Roger H. Reeves

The paper develops a transchromosomic rat model with human chromosome 21 that exhibits key Down syndrome features and provides a tool for DS research and drug development.

bioRxiv · Oct 3, 2021 · PreprintGenetics

A non-mosaic humanized mouse model of Down syndrome, trisomy of the long arm of human chromosome 21 in mouse chromosome background

Yasuhiro Kazuki, Feng J. Gao, Yicong Li, Anna J. Moyer, Benjamin Devenney, Kei Hiramatsu, Sachiko Miyagawa-Tomita, Satoshi Abe, Kanako Kazuki, Naoyo Kajitani, Narumi Uno, Shoko Takehara, Masato Takiguchi, Miho Yamakawa, Atsushi Hasegawa, , Roger H. Reeves

This paper describes a new non-mosaic humanized mouse model of Down syndrome with a nearly complete copy of the long arm of human chromosome 21.

bioRxiv · Dec 10, 2019 · PreprintGenetics