Toshimasa Yamauchi

This study shows nicotine increases intestinal stem cell stemness and tumorigenicity through Hippo-YAP/TAZ and Notch pathways, and suggests DBZ as a potential therapeutic.

Cross-population GWAS of 220 phenotypes in BioBank Japan, UK Biobank, and FinnGen (n=628,000) identifies 5,343 previously unreported loci and decomposes summary statistics into latent genetic components for disease subtyping.

The paper reports in silico structural analysis of ethnic-specific PAX4 variants associated with type 2 diabetes in a Japanese population.

A large-scale GWAS in 212,453 Japanese individuals identified 45 novel susceptibility loci for 22 diseases, highlighting the importance of non-European population studies.

This paper identifies 56 new type 2 diabetes loci in 433,540 East Asian individuals through a meta-analysis of GWAS data.

The paper shows that deletion of the Il33 gene in mice leads to insulin and leptin resistance, with improved insulin sensitivity upon IL-33 supplementation.