Lori Glenwinkel

The paper provides a comprehensive gene expression profile of all 302 neurons in the C. elegans nervous system and identifies cis-regulatory elements and adhesion proteins involved in synaptic specificity.

Transcriptomes of 52,412 neurons resolve 109 of the 118 canonical hermaphrodite neuron classes, and neuropeptide genes separate subtypes inside individual classes.

This paper creates a molecular atlas of chemoreceptor expression in C. elegans, showing their diverse expression patterns across neuron types and revealing plasticity during developmental stages.

The paper identifies pals-22 as a gene required to prevent silencing of repetitive transgenes in C. elegans somatic tissues and links it to RNAi-dependent mechanisms.