Pharmacology & ToxicologyJournal of Clinical InvestigationPeer-reviewed
Concomitant suppression of COX-1 and COX-2 is insufficient to induce enteropathy associated with chronic NSAID use
Kayla Barekat, Soumita Ghosh, Christin Herrmann…·Emanuela Ricciotti
The paper shows that suppressing both COX-1 and COX-2 does not cause intestinal injury in mice unless combined with specific NSAIDs, and that gut microbiome changes amplify NSAID-induced enteropathy.