Soumita Ghosh

This paper identifies PACERR as a lncRNA that regulates COX-2 and cholesterol transport genes, linking inflammation and cholesterol homeostasis through distinct mechanisms in response to HDL and LPS.

The paper shows that suppressing both COX-1 and COX-2 does not cause intestinal injury in mice unless combined with specific NSAIDs, and that gut microbiome changes amplify NSAID-induced enteropathy.

This study compares the metabolomic effects of naproxen and celecoxib in humans and mice, finding that naproxen reduces tryptophan levels independently of Cox-2 inhibition.

This study shows that COX-2 deletion or inhibition leads to heart failure with preserved ejection fraction in zebrafish, mice, and humans.

This study shows that disrupting the PGE2 synthesis or response pathway reduces atherogenesis in PD-1 deficient hyperlipidemic mice through different immune mechanisms.

This study shows that disrupting PGF2α receptor signaling reduces fibrosis in a mouse model of IPF by altering fibroblast dynamics and reducing fibrotic endpoints.

The paper identifies lipidomic biomarkers and therapeutic targets in sepsis patients, including those with COVID-19, and develops an interactive network analysis tool for multiomic data exploration.

This study shows that PAX4 variants reduce beta cell function and increase diabetes risk by impairing insulin secretion and hormone gene expression in human cells.

multiSLIDE is a web tool for visualizing interconnected molecular features in multi-omics data through keyword searches and customizable heatmaps.