Author

Kayla Barekat

University of Pennsylvania

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Organism:mouse· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1

Frequent Co-Authors

Aalim M. WeljieiD· 2 shared Arjun SenguptaiD· 2 shared Emanuela RicciottiiD· 2 shared Frederic D. BushmaniD· 2 shared Garret A. FitzGeraldiD· 2 shared Robin JoshiiD· 2 shared Soumita GhoshiD· 2 shared Antonijo Mrčela· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersPharmacology & Toxicology

Aalim M. WeljieORCID

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Author profile →

2 papers

Recent·Most cited

Concomitant suppression of COX-1 and COX-2 is insufficient to induce enteropathy associated with chronic NSAID use

Kayla Barekat, Soumita Ghosh, Christin Herrmann, Karl Keat, Charles‐Antoine Assenmacher, Ceylan Tanes, Naomi Wilson, Ronan Lordan, Antonijo Mrčela, Lubica Rauova, Arjun Sengupta, Ujjalkumar Subhash Das, Robin Joshi, Elliot S. Friedman, Marylyn DeRiggi Ritchie, , Emanuela Ricciotti

The paper shows that suppressing both COX-1 and COX-2 does not cause intestinal injury in mice unless combined with specific NSAIDs, and that gut microbiome changes amplify NSAID-induced enteropathy.

Journal of Clinical Investigation · Jan 27, 2026Peer-reviewedPharmacology & Toxicology

Metabolomic Response to Non-Steroidal Anti-Inflammatory Drugs

Soumita Ghosh, Nick Lahens, Kayla Barekat, Soon‐Yew Tang, Katherine N. Theken, Emanuela Ricciotti, Arjun Sengupta, Robin Joshi, Frederic D. Bushman, Aalim M. Weljie, Tilo Großer, Garret A. FitzGerald

This study compares the metabolomic effects of naproxen and celecoxib in humans and mice, finding that naproxen reduces tryptophan levels independently of Cox-2 inhibition.

bioRxiv · Nov 26, 2024 · PreprintSystems Biology