Cancer BiologybioRxivPreprint
Altered chromatin accessibility mediated by somatic cohesin mutations amplifies FLI1-Menin output to promote leukemogenesis
Jane Jialu Xu, Viviana Scoca, Yi Chen…·Aaron D. Viny
This study shows that cohesin mutations alter chromatin accessibility, enhancing FLI1-Menin interaction and promoting leukemogenesis through therapeutic vulnerabilities.