João Peça

Circadian Rhythms are Disrupted in Patients and Preclinical Models of Machado-Joseph Disease

This study investigates circadian rhythm disruptions in Machado-Joseph disease patients and preclinical models, finding impaired clock gene expression and disrupted activity and temperature rhythms.

Aberrant hippocampal transmission and behavior in mice with a stargazin mutation linked to intellectual disability

This study shows that a stargazin mutation causes cognitive and synaptic defects in mice, linking it to intellectual disability.

Constitutive ghrelin receptor activity modulates AMPA receptor traffic and supports memory formation

This study shows that constitutive ghrelin receptor activity regulates AMPA receptor trafficking and synaptic plasticity, and its inhibition impairs memory.