Jose Antonio Esteban

Astrocytic PI3Kα controls synaptic plasticity and cognitive function via serine metabolism

This study shows that astrocytic PI3Kα supports synaptic plasticity and cognitive function by regulating serine metabolism and D-serine levels necessary for NMDA receptor activation during long-term potentiation.

Microglia Rank signaling regulates GnRH function and the Hypothalamic-Pituitary-Gonadal axis

The paper shows that microglia use Rank signaling to regulate GnRH function and the HPG axis, leading to hypogonadotropic hypogonadism when disrupted.

Neurogranin enhances spontaneous activity and neuronal survival of hippocampal neurons

This study shows that neurogranin enhances spontaneous neuronal activity, network synchronization, and neuronal survival in hippocampal neurons through calcium-dependent signaling and synaptic remodeling.

Deficient Memory, Long-Term Potentiation and Hippocampal Synaptic Plasticity in Galectin-4-Deficient Mice

This study shows that galectin-4 deficiency in mice alters gut microbiota, impairs memory, and disrupts hippocampal synaptic plasticity.

SFRP1 upregulation causes hippocampal synaptic dysfunction and memory impairment

This study shows that SFRP1 overexpression in astrocytes causes synaptic dysfunction and memory impairment in mice, suggesting SFRP1 as a therapeutic target for Alzheimer's disease.

Cyclin D1-Cdk4 regulates neuronal activity through phosphorylation of GABAA receptors

This study identifies Ccnd1-Cdk4 as a regulator of GABAAR activity through phosphorylation, affecting neuronal signaling and synaptic pruning in mice.

Constitutive ghrelin receptor activity modulates AMPA receptor traffic and supports memory formation

This study shows that constitutive ghrelin receptor activity regulates AMPA receptor trafficking and synaptic plasticity, and its inhibition impairs memory.